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Inhibitors

Enzyme inhibitors are molecules that interact in certain ways with the enzyme to prevent it from functioning in a normal manner. They can alter the catalytic action of the enzyme and consequently slow down, or even stop catalysis. Inhibitors can act in various modes when interacting with the enzyme: reversible or irreversible inhibition, covalent binding or non-covalent binding, as well as specific or nonspecific inhibition. Based on the inhibition kinetics, enzyme inhibition can be categorized into three major types: competitive inhibition, non-competitive inhibition, and uncompetitive inhibition.

Competitive Inhibition

Competitive inhibition occurs when an inhibitor and a substrate both tend to bind to the enzyme in an exclusive manner. A competitive inhibitor could be any compound that closely resembles the chemical structure and molecular geometry of the substrate. The inhibitor competes for the same active site with the substrate molecule. Upon binding, interactions between the inhibitor and the enzyme may be strong in the active site, but no reaction would happen because the inhibitor does not carry the same chemical reactivity. As a result, the inhibitor is "stuck" on the enzyme and prevents any substrate molecules from reacting with the enzyme, and thus the reaction rate is decreased. However, a competitive inhibition is usually temporary and reversible. Therefore, the level of inhibition depends upon the relative concentrations of the substrate and inhibitor, as well as the relative affinities of the inhibitor and substrate to the active site, since they are competing for places in the enzyme active sites.

Non-Competitive Inhibition

Non-competitive inhibitors bind to the enzyme regardless of whether the active site is already occupied by the substrate. In fact, the enzyme could be in complexes with either the substrate or inhibitor, or both during non-competitive inhibition. A common form of non-competitive inhibition is called allosteric inhibition, where the inhibitor does not bind to the active site, but the allosteric site. Binding to an allosteric site distorts the 3-dimensional tertiary structure of the enzyme, such that it can no longer catalyze a reaction. There are also other mechanisms of non-competitive inhibition than allosteric inhibition. For example, both the substrate and inhibitor could bind to the active site at the same time. Some non-competitive inhibitors are irreversible and permanent because they denature the enzymes effectively. However, there are also non-competitive inhibitors reversibly and non-permanently stops the enzymatic reaction, which are vital in controlling metabolic functions in organisms.

Uncompetitive Inhibition

Uncompetitive inhibition is not commonly seen. An uncompetitive inhibitor binds to the enzyme and enhances the binding affinity of the substrate, but the resultant enzyme-inhibitor-substrate complex undergoes reaction to form the product very slowly. It should be noted that uncompetitive inhibition requires the formation of an enzyme-substrate complex prior to binding to the inhibitor. To the contrary, non-competitive inhibition can occur with or without the substrate present.

Application of the Enzyme Inhibitors

Enzyme inhibitors play important roles in pharmaceutical and biochemical industries. They can be widely used in metabolic control, as metabolic poisons and medicines. For example, many poisons work by inhibiting the action of enzymes involved in metabolic processes, which defends a plant or animal against predators. In addition, some enzyme inhibitors can be used as drugs in the treatment of various diseases. Some antimicrobial drugs are enzyme inhibitors that deactivate the enzymes that are needed for the survival of pathogens.

Creative Enzymes gladly supply various enzyme inhibitors of premier grade to the customers. We persist in being the most reliable supplier for enzyme products in the global market. Today, Creative Enzymes is a leading company in enzymes and enzyme-related products, and is well known for the high level of customer satisfaction. We deliver the products in a momentary span of time from order placement to final delivery. Our prompt service, dedicated customer care, and reliable approaches have made us the most preferred vendor.

Catalog Product Name EC No. CAS No. Source Price
CEI-1442 Necrostatin 2 852391-19-6 Inquiry
CEI-1441 NBD-557 333352-59-3 Inquiry
CEI-1440 NB-598 Maleate 155294-62-5 Inquiry
CEI-1439 NB-598 hydrochloride 136719-25-0 Inquiry
CEI-1438 Narlaprevir 865466-24-6 Inquiry
CEI-1437 N3PT 13860-66-7 Inquiry
CEI-1436 MRT67307 1190378-57-4 Inquiry
CEI-1435 MLN4924 HCl salt 1160295-21-5 Inquiry
CEI-1434 MLN 2480 1096708-71-2 Inquiry
CEI-1433 MK-8245 1030612-90-8 Inquiry
CEI-1432 MK-8033 1001917-37-8 Inquiry
CEI-1431 MK591 147030-01-1 Inquiry
CEI-1430 MK-5172 sodium salt 1425038-27-2 Inquiry
CEI-1429 MK-5172 potassium salt 1206524-86-8 Inquiry
CEI-1428 MK-5172 hydrate 1350462-55-3 Inquiry
CEI-1427 MK-5172 1350514-68-9 Inquiry
CEI-1426 MK-2894 1006036-87-8 Inquiry
CEI-1425 MK-2048 869901-69-9 Inquiry
CEI-1424 MK-0591 136668-42-3 Inquiry
CEI-1423 MK 0893 870823-12-4 Inquiry
CEI-1422 MI-3 1271738-59-0 Inquiry
CEI-1421 MI-2 1271738-62-5 Inquiry
CEI-1420 MF63 892549-43-8 Inquiry
CEI-1419 Mercaptopurine (6-MP) 50-44-2 Inquiry
CEI-1418 MEK162 (ARRY-162, ARRY-438162) 606143-89-9 Inquiry
CEI-1417 MEK inhibitor 334951-92-7 Inquiry
CEI-1416 MDV3100 (Enzalutamide) 915087-33-1 Inquiry
CEI-1415 MC1568 852475-26-4 Inquiry
CEI-1414 MAC13243 1071638-38-4 Inquiry
CEI-1413 LY-411575 209984-57-6 Inquiry