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Zymogens

Creative Enzymes is one of the few companies in the world that have the ability to supply a variety of zymogens. We are proudly composed of groups of brilliant scientists who are devoting themselves to high-grade products and satisfying services. Our products include different types of zymogens: human zymogens, bovine zymogens, and mouse zymogen. As a renowned supplier, Creative Enzymes offers the products with high quality and competitive cost performance. The unique and superior products distinguish Creative Enzymes from our competitors.

Zymogens are a group of proteins that display no catalytic activity but can be transformed into active enzymes within an organism. A zymogen is an inactive precursor of an enzyme, especially those that catalyze reactions involving the breakdown of proteins. Zymogens require a biochemical change, such as the change of configuration or a hydrolysis reaction to reveal the active site, to become an active enzyme. For this reason, a zymogen is also called a proenzyme.

Zymogens, rather than active enzymes, are typically secreted by the human body, because they can be stored and transported safely without harms to surrounding tissues, and released when conditions are favorable for optimal activity. Most of the digestive proteases produced in the pancreas are expressed as zymogens and retained in such form in zymogen granules. The contents of these granules are only released into the small intestine during eating, and the zymogens are only activated once they enter the small intestine. The latter step is initiated by an intestinal protease, enterokinase. For example, pepsin is synthesized in the form of pepsinogen, an inactive zymogen which is secreted by the chief cells. Pepsin becomes active once pH drops below 5, and works optimally at pH 2-3 in the acidic environment of the stomach. Activation of pepsinogen starts with the hydrocholoric acid (HCl), which is secreted by the parietal cells. The acid partially activates pepsinogen by drastically lowering pH. The partially activated pepsinogen is then completely activated and turned into pepsinby another pepsinogen through cleavage of a short peptide. Under rare circumstances, incorrect activation of these zymogens within the pancreas could result inpancreatitis and lead to devastating consequences.

Creative Enzymes serves the customers with all kinds of zymogens, which can be classified into three different sources: human, bovine, and mouse. Each species then can be subdivided into either one or more types of enzyme cascades, such as the coagulation cascade of prothrombin or protein C. The purity of all these products is above 90%, which is determined by SDS-PAGE analysis. These zymogens are considered to play critical roles in various biochemistry reactions such as calcium ion binding, peptidase activity, phospholipid binding, protein binding, and serine-type endopeptidase activity.

For many years, Creative Enzymes has been manufacturing and distributing a variety of enzymes and zymogens used in multiple research areas. By constantly striving for utmost quality, Creative Enzymes has earned the trust of countless customers, and is proud to offer highly sophisticated research products. Creative Enzymes is committed to achieving the highest level of customer satisfaction, and to continuously improving its products, services, and quality management.

Catalog Product Name EC No. CAS No. Source Price
ENLC-002 ω-Transaminases Inquiry
CZY-030 Bovine Plasminogen Bovine Inquiry
CZY-029 Human Kininogen (Two Chain High Molecular Weight) Human Inquiry
CZY-028 Human Kininogen (Single Chain High Molecular Weight) Human Inquiry
CZY-027 Human Prekallikrein Human Inquiry
CZY-026 Mouse Prothrombin Mouse Inquiry
CZY-025 Bovine Prothrombin Bovine Inquiry
CZY-024 Human Prethrombin-2 Human Inquiry
CZY-023 Human Prethrombin-1 Human Inquiry
CZY-022 Human Prothrombin Fragment 2 78768-79-3 Human Inquiry
CZY-021 Human Prothrombin Fragment 1.2 Human Inquiry
CZY-020 Human Prothrombin Fragment 1 72270-84-9 Human Inquiry
CZY-019 Human Prothrombin 9001-26-7 Human Inquiry
CZY-018 Bovine Protein C Bovine Inquiry
CZY-017 Human Protein C 42617-41-4 Human Inquiry
CZY-016 Mouse glu-Plasminogen Mouse Inquiry
CZY-015 Bovine glu-Plasminogen Bovine Inquiry
CZY-014 Human lys-Plasminogen Human Inquiry
CZY-013 Human glu-Plasminogen CHOII Human Inquiry
CZY-012 Human glu-Plasminogen CHOI Human Inquiry
CZY-011 Human glu-Plasminogen 9001-91-6 Human Inquiry
CZY-010 Human Factor XIII 9013-56-3 Human Inquiry
CZY-009 Human Factor XII 9001-30-3 Human Inquiry
CZY-008 Human Factor XI 9013-55-2 Human Inquiry
CZY-007 Mouse Factor X Mouse Inquiry
CZY-006 Bovine Factor X 9002-05-5 Bovine Inquiry
CZY-005 Human gla-domainless Factor X Human Inquiry
CZY-004 Human Factor X 9001-29-0 Human Inquiry
CZY-032 Mouse factor IX Mouse Inquiry
CZY-003 Bovine factor IX 9001-28-9 Bovine Inquiry