Products

Enzymes for Research, Diagnostic and Industrial Use

Products
Online Inquiry

Our Products Cannot Be Used As Medicines Directly For Personal Use.

24 hour
Promise

Welcome! For price inquiries, please feel free to contact us through the form on the left side. We will get back to you as soon as possible.

ARQ 197 (Tivantinib)

Cat No.
CEI-0006
Description
ARQ 197 (Tivantinib) can inhibit c-Met with IC50 of 100 nM
CAS No.
905854-02-6
Molecular Weight
369.42
Purity
>99%
Storage
2 years at -20 centigrade
Targets
c-Met
Molecular Formula
C23H19N3O2
Chemical Name
(3R,4R)-3-(2,3-dihydro-1H-pyrrolo[3,2,1-ij]quinolin-6-yl)-4-(1H-indol-3-yl)pyrrolidine-2,5-dione
Solubility
DSMO 74 mg/mL Water
In vitro
Tivantinib, an oral, non-ATP competitive, selective c-MET inhibitor. Treatment of cells with tivantinib resulted in a comparable concentration-dependent decrease in cell viability with GI 50 values of 1.2 and 3.7 mmol/L obtained in MDA-MB-231/TGL and 1833/TGL cells,
In vivo
Treatment with tivantinib at the doses of 60 and 120 mg/kg induced a dose-dependent delay and a reduction of bone metastatic growth.
0
Click unfold / close
Inquiry Basket
Delete selected Quote Check Out
Decide to move out of the shopping cart?
Sure No, Back

Please choose product!

< Go Back
You have already added to buy this product