In enzymology, a N-acylneuraminate cytidylyltransferase (EC 126.96.36.199) is an enzyme that catalyzes the chemical reaction:CTP + N-acylneuraminate↔ diphosphate + CMP-N-acylneuraminate. Thus, the two substrates of this enzyme are CTP and N-acylneuraminate, whereas its two products are diphosphate and CMP-N-acylneuraminate. This enzyme belongs to the family of transferases, specifically those transferring phosphorus-containing nucleotide groups (nucleotidyltransferases). This enzyme participates in aminosugars metabolism.
Acid Synthetase, Recombinant (Neisseria meningitidis group B)
Neisseria meningitidis group B
The enzyme has been utilized to synthesize CMP-sialic acid and its derivatives.
, Supplied as a lyophilized powder containing Tris-HCl and NaCl.
Enzyme Commission Number
> 10 units/mg protein
One unit will catalyze the formation of 1 μmol CMP-Neu-5-Ac from Neu-5-Ac and CTP per minute at 37°C at pH 8.0.
EC 188.8.131.52; N-acylneuraminate cytidylyltransferase; CMP-sialate pyrophosphorylase; CMP-sialate synthase; cytidine 5'-monophosphosialic acid synthetase; CMP-Neu5Ac synthetase; CMP-NeuAc synthetase; acylneuraminate cytidyltransferase; CMP-N-acetylneuraminate synthetase; CMP-N-acetylneuraminate synthase; CMP-N-acetylneuraminic acid synthase; CMP-NANA synthetase; CMP-sialate synthetase; CMP-sialic synthetase; cytidine 5'-monophospho-N-acetylneuraminic acid synthetase; cytidine 5-monophosphate N-acetylneuraminic acid synthetase; cytidine monophosphosialic acid synthetase; cytidine monophosphoacetylneuraminic synthetase; cytidine monophosphosialate pyrophosphorylase; cytidine monophosphosialate synthetase; acetylneuraminate cytidylyltransferase