Histamine dehydrogenase is a homodimeric enzyme and catalyzes oxidative deamination of histamine. The gene encoding this enzyme has been sequenced and cloned by polymerase chain reactions and overexpressed in Escherichia coli.
Histamine Dehydrogenase, Recombinant (E. coli)
Enzyme Commission Number
> 1 U/mg lyophilizate
ca. 150 kDa
1.0 x 10^-5 M (histamine)
2 subunits of ca. 71 kDa (SDS-PAGE)
histamine (100), agmatine (7), putrescine (0), cadaverine (0)
One unit (U) is defined as the amount of enzyme which produces 1 μmol of 4-imidazolylacetoaldehyde per min at 37°C and pH 9.0.
Stability (liquid form) stable at 37°C for at least four weeks Stability (powder form) stable at 50°C for at least two weeks
Histamine : (acceptor) oxidoreductase (deaminating); EC 1.4.99; Histamine Dehydrogenase