HGPRT is a highly active enzyme that catalyzes the reversible transfer of the 5-phosphoribosyl group between α-D-5-phosphoribosyl-1-pyrophosphate (PRPP) and a purine base (hypoxanthine or guanine) to form a purine nucleotide IMP or GMP. The enzyme has been characterized for its affinity for natural substrates and velocity in forward and reverse directions.
HGPRT, Recombinant (Human)
Enzyme Commission Number
> 1 Unit/mg protein
One unit of hypoxanthine-guanine phosphoribosyl transferase converts 1 µmole of hypoxanthine to IMP per minute at pH 8.8 at 25°C.
HPRT enzyme is provided in lyophilized form and should be stored at –20°C.
Hypoxanthine phosphoribosyltransferase; HGPRTase; HPRT; Hypoxanthine-guanine phosphoribosyltransferase; HGPRT; EC 220.127.116.11