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Native Human Cathepsin L
Cat No.
NATE-0177
Description
Cathepsin L (EC 3.4.22.15, Aldrichina grahami cysteine proteinase) is an important lysosomal endopeptidase enzyme which is involved in the initiation of protein degradation. It is a member of the Peptidase C1 family, which play an important role in diverse processes including normal lysosome mediated protein turnover, antigen and proprotein processing, and apoptosis. Cathepsin L has been reported in many organisms including fish, birds and mammals.
Abbr
CTSL, Native (Human)
Alias
CTSL
Source
Human liver
Species
Human
Applications
The most powerful of the lysosomal proteinases. It has a higher specific activity than cathepsin B and H in the degradation of a variety of physiological protein substrates.
Form
Solution in in 20 mM malonate, pH 5.5, 1 mM EDTA, and 400 mM NaCl.
Enzyme Commission Number
EC 3.4.22.15
Activity
> 0.5 units/mg protein
CAS No.
60616-82-2
Unit Definition
One unit will hydrolyze 1.0 μmole of Z-Phe-Arg-AFC per minute at pH 5.5 at 25°C.
Storage
−20°C
Pathway
Adaptive Immune System, organism-specific biosystem; Antigen processing and presentation, conserved biosystem; Endosomal/Vacuolar pathway, organism-specific biosystem
Function
collagen binding; cysteine-type peptidase activity; histone binding
Synonyms
cathepsin L; CTSL; EC 3.4.22.15; Aldrichina grahami cysteine proteinase; 60616-82-2
Download
Download Datasheet| Catalog | Product Name | EC No. | CAS No. | Source | Price |
|---|---|---|---|---|---|
| NATE-1665 | Cathepsin L from Human, Recombinant | EC 3.4.22.15 | E. coli | Inquiry | |
| EXWM-4195 | cathepsin L | EC 3.4.22.15 | 60616-82-2 | Inquiry |