Catalase activates the decomposition of hydrogen peroxide, a reactive oxygen species, into water and oxygen. It functions as a natural antioxidant, protecting cells against oxidative damage to proteins, lipids and nucleic acids. Catalase has also been used to study the role reactive oxygen species play in gene expression and apoptosis.
CAT, Native (Murine)
ammonium sulfate suspension
Enzyme Commission Number
> 500 units/mg protein
tetramer mol wt ~250 kDa
One unit will decompose 1.0 μmole of H2O2 per min at pH 7.0 at 25°C, while the H2O2 conc. falls from 10.3 to 9.2 mM.
Suspension in 2.7 M (NH4)2SO4 solution, pH 6.5
Amyotrophic lateral sclerosis (ALS), organism-specific biosystem; Cellular responses to stress, organism-specific biosystem; FoxO signaling pathway, organism-specific biosystem
NADP binding; aminoacylase activity; antioxidant activity
EC 220.127.116.11; Catalase; catalase; equilase; caperase; optidase; catalase-peroxidase; CAT; H2O2:H2O2 oxidoreductase