Carnitine acetyltransferase maintains the cellular and mitochondrial levels of acetyl-CoA, a key cofactor required for oxidative metabolism, by catalyzing an equilibrium between acetyl-CoA and acetyl-L-carnitine, a storage form of activated acetate. Carnitine acetyltransferase also maintains the pool of acetyl-CoA required for neuronal and nonneuronal acetylcholine production.
CRAT, Native (Pigeon)
Pigeon breast muscle
Protein determined by biuret.
ammonium sulfate suspension. Crystalline suspension in 3.2 M (NH4)2SO4 solution, 50 mM potassium phosphate, 1 mM dithiothreitol, pH 7.0
Enzyme Commission Number
> 70 units/mg protein
One unit will convert 1.0 μmole of acetyl-L-carnitine and CoA to L-carnitine and acetyl-CoA per min at pH 8.0 at 25°C.
Peroxisome, organism-specific biosystem; Peroxisome, conserved biosystem
carnitine O-acetyltransferase; Carnitine acetylase; carnitine acetyltransferase
acetyl-CoA-carnitine O-acetyltransferase; acetylcarnitine transferase; carnitine acetyl coenzyme A transferase; carnitine acetylase; carnitine acetyltransferase; carnitine-acetyl-CoA transferase; CATC; 9029-90-7; carnitine O-acetyltransferase; EC 18.104.22.168; CRAT; CAT