Protein kinase C is a family of protein kinase enzymes that are involved in controlling the function of other proteins through the phosphorylation of hydroxyl groups of serine and threonine amino acid residues on these proteins. PKC enzymes in turn are activated by signals such as increases in the concentration of diacylglycerol (DAG) or calcium ions (Ca2+). Hence PKC enzymes play important roles in several signal transduction cascades.
Type I, buffered aqueous glycerol solution; Type II, lyophilized powder.
Enzyme Commission Number
Type I, 50-200 units/mL
mol wt 82 kDa by SDS-PAGE
One unit will transfer 1 nmol of phosphate per min from ATP to histone H1 at pH 7.4 at 30°C.
Solution in 50% glycerol containing 20 mM Tris, pH 7.5, 0.5 mM EDTA, 0.5 mM EGTA, 5 mM DTT, 100 mM NaCl, 0.02% Tween 20, and 1 μg/ml leupeptin.
EC 184.108.40.206; 141436-78-4; Protein kinase C; PKC; calcium-dependent protein kinase C; calcium-independent protein kinase C; calcium/phospholipid dependent protein kinase; cPKCα; cPKCβ; cPKCγ; nPKCδ; nPKCε; nPKCη; nPKCθ; PKCα; PKCβ; PKCγ; PKCδ; PKCε; PKCζ; Pkc1p; protein kinase Cε; STK24