Products

Enzymes for Research, Diagnostic and Industrial Use

Protein kinase Cα isozyme human, Recombinant

Cat No.
NATE-0574
Description
Protein Kinase C (PKC) is a serine/threonine kinase that is activated intracellularly by signal transduction pathways that produce DAG from phosphatidylinositol diphosphate (PIP2) and phosphatidylcholine (PC) through the action of various activated phospholipases. Phorbol esters also stimulate PKC. At least 11 PKC isozymes have been identified that differ in primary structure, tissue distribution, subcellular localization, response to extracellular signals, and substrate specificity. The isozymes can be grouped into three subfamilies. Members of the first family require Ca2+ and phospholipid and include PKCα, βI, βII, and γ. Members of the second family are phospholipid-dependent but Ca2+-independent, and include PKCδ, ε, η, and θ. Members of the third family are not activated by either DAG or phorbol esters and include PKCξ, μ, and ι.
Abbr
PKCA, Recombinant (Human)
Alias
PRKCA; PKCA; PKCα
Source
baculovirus infected insect cells
Species
Human
Product Overview
> 70% (SDS-PAGE), recombinant, expressed in baculovirus infected insect cells, buffered aqueous glycerol solution
Form
buffered aqueous glycerol solution
Molecular Weight
mol wt 80-81 kDa by SDS-PAGE
Purity
> 70% (SDS-PAGE)
Unit Definition
One unit will transfer 1 pmol of phosphate to CREBtide in 1 min at pH 7.2 at 30°C
Stability
−70°C
Buffer
Solution in 50 mM Tris-HCl, pH 7.5, 150 mM NaCl, 10 mM glutathione, 0.1 mM EDTA, 0.1 mM PMSF, 25% glycerol and 0.25 mM DTT
Pathway
ATF-2 transcription factor network, organism-specific biosystem; African trypanosomiasis, organism-specific biosystem; African trypanosomiasis, conserved biosystem; Aldosterone-regulated sodium reabsorption, organism-specific biosystem; Aldosterone-regulated sodium reabsorption, conserved biosystem; Alpha6-Beta4 Integrin Signaling Pathway, organism-specific biosystem; Amoebiasis, organism-specific biosystem
Function
ATP binding; enzyme binding; histone kinase activity (H3-T6 specific); metal ion binding; nucleotide binding; protein binding; protein kinase C activity; protein kinase activity; protein kinase activity; protein serine/threonine kinase activity; zinc ion binding
Synonyms
PRKCA; protein kinase C, alpha; PKCA; protein kinase C alpha type; PKC-A; PKCα; AAG6; PKC-alpha; PRKACA
Download Datasheet:


“PKC” Total Products Page

Inquiry
Realted Products
Catalog
ProductName
EC No.
CAS No.
Source
Price
CatalogNATE-0573
EC No.EC 2.7.1.37
CAS No.141436-78-4
SourceRat brain
CatalogNATE-0575
EC No.EC 2.7.1.37
CAS No.
Sourcebaculovirus infected insect cells
CatalogNATE-0576
EC No.EC 2.7.1.37
CAS No.
Sourcebaculovirus infected insect cells
CatalogNATE-0577
EC No.
CAS No.
SourceE. coli
+ See More >>
Online Inquiry
Name:
*Phone:
*E-mail Address:
Country:
Company/Institution:
*Products or Services Interested:
Quantity:
Project Description:
*Verification Code:
Please input "enzymes"(case insensitive) as verification code.

Welcome! For price inquiries, please feel free to contact us through the form below through the form on the left side. We will get back to you as soon as possible.

Sitemap  Privacy Policy
Copyright ©2011 - 2017 Creative Enzymes.
Contact Us 45-1 Ramsey Road, Shirley, NY 11967, USA
Email: info@creative-enzymes.com
Tel: 1-631-562-8517 1-631-448-7888
Fax: 1-631-938-8127
Distributors To view the contact information for a specific location, select the desired country: