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Native Human Cathepsin B
Cat No.
NATE-0169
Description
Cathepsin B has been found to cleave procaspase 1 and procaspase 11 and to induce apoptosis in digitonin-permeabilized cells. Translocation of cathepsin B from the cytoplasm to the nucleus contributes to bile salt induced apoptosis of rat hepatocytes. Levels of cathepsin B in PC12 cells significantly decrease 12 to 24 hours after apoptosis is induced.
Abbr
CTSB, Native (Human)
Alias
CTSB; APPS; CPSB
Source
Human placenta
Species
Human
Applications
Cathepsin B is a lysosomal cysteine proteinase which hydrolyzes proteins with a broad specificity for peptide bonds. Cathepsin B may be a useful tool in Alzheimer’s research, as it may have a role in the natural defense against the disease. Cathepsin B may be used to cleave procaspase 1 and procaspase 11, and to induce apoptosis in digitonin-permeabilized cells.
Form
Lyophilized powder containing phosphate buffer salts
Enzyme Commission Number
EC 3.4.22.1
Activity
> 5 units/mg protein
CAS No.
9047-22-7
Composition
Protein, ~50% Lowry
Unit Definition
One unit will liberate 1 nanomole of 7-amino-4-methylcoumarin from Z-Arg-Arg 7-amido-4-methylcoumarin per min at pH 6.0 at 40°C.
Pathway
Antigen processing and presentation, organism-specific biosystem; Antigen processing and presentation, conserved biosystem; Immune System, organism-specific biosystem; Innate Immune System, organism-specific biosystem; Lysosome, organism-specific biosystem; Lysosome, conserved biosystem; Toll Receptor Cascades, organism-specific biosystem
Function
cysteine-type endopeptidase activity; cysteine-type peptidase activity; kininogen binding; peptidase activity; peptide binding; protein binding
Synonyms
CTSB; cathepsin B; cathepsin B1; APPS; CPSB; EC 3.4.22.1; 9047-22-7; cathepsin II; CatB
Download
Download Datasheet"Cathepsin B" Total Products Page
| Catalog | Product Name | EC No. | CAS No. | Source | Price |
|---|---|---|---|---|---|
| NATE-1706 | Cathepsin B from Human, recombinant | EC 3.4.22.1 | 9047-22-7 | E. coli | Inquiry |
| NATE-0167 | Native Bovine Cathepsin B | 9047-22-7 | Bovine spleen | Inquiry | |
| NATE-0168 | Native Human Cathepsin B | EC 3.4.22.1 | 9047-22-7 | Human liver | Inquiry |
| EXWM-4192 | cathepsin B | EC 3.4.22.1 | 9047-22-7 | Inquiry |