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uPA

Official Full Name
uPA
Background
Urokinase or Urokinase-type plasminogen activator (uPA) is a serine protease (EC 3.4.21.73). It is secreted as a single-chain zymogen, pro-Urokinase, possessing little or no intrinsic enzymatic activity. The single chain zymogen is converted into the active two chain enzyme (tcuPA) by cleavage of the bond between Lys157 and Ile158. After activation, Urokinase specifically cleaves the proenzyme plasminogen to form the active enzyme plasmin. The active plasmin then catalyzes the breakdown of fibrin polymers of blood clots. Urokinase is involved in a number of biological functions including fibrinolysis, embryogenesis, cell migration, tissue remodeling, ovulation, and wound healing. Additionally, it is a potent marker of invasion and metastasis in a variety of human cancers associated with breast, stomach, colon, bladder, ovary, brain and endometrium.
Synonyms
Two chain urokinase-type plasminogen activator; tcuPA; PLAU; ATF; UPA; URK; u-PA; BDPLT5; QPD; Urokinase
Catalog Product Name EC No. CAS No. Source Price
NATE-1690 Urokinase from Human, recombinant EC 3.4.21.73 E. coli Inquiry
EXWM-4165 u-plasminogen activator EC 3.4.21.73 9039-53-6 Inquiry
PHAM-263 Native Human Urokinase EC 3.4.21.73 9039-53-6 Human kidney ce... Inquiry
PHAM-262 Native Human Urokinase EC 3.4.21.73 9039-53-6 Human urine Inquiry