Products

Enzymes for Research, Diagnostic and Industrial Use

Products
Online Inquiry

Our Products Cannot Be Used As Medicines Directly For Personal Use.

24 hour
Promise

Welcome! For price inquiries, please feel free to contact us through the form on the left side. We will get back to you as soon as possible.

Inhibitors

Enzyme inhibitors are molecules that interact in certain ways with the enzyme to prevent it from functioning in a normal manner. They can alter the catalytic action of the enzyme and consequently slow down, or even stop catalysis. Inhibitors can act in various modes when interacting with the enzyme: reversible or irreversible inhibition, covalent binding or non-covalent binding, as well as specific or nonspecific inhibition. Based on the inhibition kinetics, enzyme inhibition can be categorized into three major types: competitive inhibition, non-competitive inhibition, and uncompetitive inhibition.

Competitive Inhibition

Competitive inhibition occurs when an inhibitor and a substrate both tend to bind to the enzyme in an exclusive manner. A competitive inhibitor could be any compound that closely resembles the chemical structure and molecular geometry of the substrate. The inhibitor competes for the same active site with the substrate molecule. Upon binding, interactions between the inhibitor and the enzyme may be strong in the active site, but no reaction would happen because the inhibitor does not carry the same chemical reactivity. As a result, the inhibitor is "stuck" on the enzyme and prevents any substrate molecules from reacting with the enzyme, and thus the reaction rate is decreased. However, a competitive inhibition is usually temporary and reversible. Therefore, the level of inhibition depends upon the relative concentrations of the substrate and inhibitor, as well as the relative affinities of the inhibitor and substrate to the active site, since they are competing for places in the enzyme active sites.

Non-Competitive Inhibition

Non-competitive inhibitors bind to the enzyme regardless of whether the active site is already occupied by the substrate. In fact, the enzyme could be in complexes with either the substrate or inhibitor, or both during non-competitive inhibition. A common form of non-competitive inhibition is called allosteric inhibition, where the inhibitor does not bind to the active site, but the allosteric site. Binding to an allosteric site distorts the 3-dimensional tertiary structure of the enzyme, such that it can no longer catalyze a reaction. There are also other mechanisms of non-competitive inhibition than allosteric inhibition. For example, both the substrate and inhibitor could bind to the active site at the same time. Some non-competitive inhibitors are irreversible and permanent because they denature the enzymes effectively. However, there are also non-competitive inhibitors reversibly and non-permanently stops the enzymatic reaction, which are vital in controlling metabolic functions in organisms.

Uncompetitive Inhibition

Uncompetitive inhibition is not commonly seen. An uncompetitive inhibitor binds to the enzyme and enhances the binding affinity of the substrate, but the resultant enzyme-inhibitor-substrate complex undergoes reaction to form the product very slowly. It should be noted that uncompetitive inhibition requires the formation of an enzyme-substrate complex prior to binding to the inhibitor. To the contrary, non-competitive inhibition can occur with or without the substrate present.

Application of the Enzyme Inhibitors

Enzyme inhibitors play important roles in pharmaceutical and biochemical industries. They can be widely used in metabolic control, as metabolic poisons and medicines. For example, many poisons work by inhibiting the action of enzymes involved in metabolic processes, which defends a plant or animal against predators. In addition, some enzyme inhibitors can be used as drugs in the treatment of various diseases. Some antimicrobial drugs are enzyme inhibitors that deactivate the enzymes that are needed for the survival of pathogens.

Creative Enzymes gladly supply various enzyme inhibitors of premier grade to the customers. We persist in being the most reliable supplier for enzyme products in the global market. Today, Creative Enzymes is a leading company in enzymes and enzyme-related products, and is well known for the high level of customer satisfaction. We deliver the products in a momentary span of time from order placement to final delivery. Our prompt service, dedicated customer care, and reliable approaches have made us the most preferred vendor.

Catalog Product Name EC No. CAS No. Source Price
CEI-0615 IWP-3 687561-60-0 Inquiry
CEI-0614 Gö 6976 136194-77-9 Inquiry
CEI-0613 IBMX 28822-58-4 Inquiry
CEI-0612 Calyculin A 101932-71-2 Inquiry
CEI-0611 Okadaic acid 78111-17-8 Inquiry
CEI-0610 Mifepristone 84371-65-3 Inquiry
CEI-0609 RO 20-1724 29925-17-5 Inquiry
CEI-0608 Zaprinast 37762-06-4 Inquiry
CEI-0607 T0070907 313516-66-4 Inquiry
CEI-0606 DPQ 129075-73-6 Inquiry
CEI-0605 DR2313 284028-90-6 Inquiry
CEI-0604 NU 1025 90417-38-2 Inquiry
CEI-0603 MDBN 1485-00-3 Inquiry
CEI-0602 DBeQ 177355-84-9 Inquiry
CEI-0601 Pifithrin-α, Cyclic, hydrobromide 511296-88-1 Inquiry
CEI-0600 Pifithrin-α 63208-82-2 Inquiry
CEI-0599 C646, p300/CBP Inhibitor 328968-36-1 Inquiry
CEI-0598 Garcinol 78824-30-3 Inquiry
CEI-0597 Anacardic Acid 16611-84-0 Inquiry
CEI-0596 CID 2745687 264233-05-8 Inquiry
CEI-0595 IWP-2 686770-61-6 Inquiry
CEI-0594 ML130 799264-47-4 Inquiry
CEI-0593 L-NMMA acetate 53308-83-1 Inquiry
CEI-0592 L-NAME hydrochloride 51298-62-5 Inquiry
CEI-0591 FK-866 658084-64-1 Inquiry
CEI-0590 BAY 11-7082 19542-67-7 Inquiry
CEI-0589 Rocaglamide 84573-16-0 Inquiry
CEI-0588 Triptolide 38748-32-2 Inquiry
CEI-0587 Sauchinone 177931-17-8 Inquiry
CEI-0586 PDTC 5108-96-3 Inquiry