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αA-Conotoxin OIVA

Cat No.
CEI-1181
Description
αA-Conotoxin OIVA (αA-OIVA) is a peptidyl toxin originally isolated from Conus obscures and belongs to the family of short αA-conotoxins (αAS) which includes αA-OIVA, αA-OIVB, αA-PeIVA, and αA-PeIVB. αA-Conotoxin OIVA blocks the fetal muscular subtype nicotinic acetylcholine receptor (α1/β1/γ/δ subunits) (IC50 = 0.51 nM) with 600-fold greater affinity than the adult subtype (IC50 = 310 nM). It completely blocks the elicited currents and it dissociates very slowly from the fetal muscle receptor. This toxin causes an apparently irreversible paralysis upon intramuscular injection into gold fish.
Abbr
αA-OIVA
Source
Synthetic peptide
Product Overview
A Blocker of α1/β1/γ/δ (fetal muscle) nAChR
Molecular Weight
1848 Da
Purity
>99%
Storage
Lyophilized powder can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.
Synonyms
Alpha-A-O4a, Alpha-A-OIVA
Targets
α1/β1/γ/δ nAChR
Molecular Formula
C70H110N24O23S6
Amino Acid Sequence
CCGVXNAACHXCVCKNTC
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