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α-Lipoic Acid

Cat No.
COEC-041
Description
α-Lipoic Acid is a metabolic antioxidant that regulates NFκB signal transduction and can protect against oxidative injury. The exogenous compound is reduced intracellularly by enzymes. Its reduced form is involved in radical scavenging, recycling of other antioxidants, accelerating GSH synthesis, and regulating transcription factor activity, specifically NFkappaB. It also acts as a conenzyme that is required for the activity of pyruvate dehydrogenase and glycine decarboxylase, among other enzyme complexes. Studies show that it can prevent a decrease in the renal antioxidant defense system and prevent the increase of lipid peroxidation, platinum content and plasma creatinine concentrations. In other studies, lipoic acid decreased the phagocytosis of myelin by macrophages, acting as a non-specific scavenger of reactive oxygen species (ROS).
Applications
A metabolic antioxidant that regulates NF-κB signal transduction
Form
Solid
CAS No.
1077-28-7
Molecular Weight
206.32
Purity
≥95%
Synonyms
DL-Thioctic Acid; DL-6,8-Dithiooctanoic acid; 1,2-Dithiolane-3-valeric acid
Molecular Formula
C8H14O2S2
Melting Point
160 to 165°C
Solubility
Solubility Soluble in ethanol or methanol
Boiling Point
362.5°C
Refractive Index
~1.75 (Predicted)
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