Products

Enzymes for Research, Diagnostic and Industrial Use

Products
Online Inquiry

Our Products Cannot Be Used As Medicines Directly For Personal Use.

24 hour
Promise

Welcome! For price inquiries, please feel free to contact us through the form on the left side. We will get back to you as soon as possible.

4-Methylumbelliferone

Cat No.
CEI-0375
Description
4-Methylumbelliferone
Alias
4-MU
CAS No.
90-33-5
Molecular Weight
176.17
Purity
>99%
Storage
2 years at -20 centigrade
Synonyms
4-MU
Targets
HA synthesis
Molecular Formula
C10H8O3
Chemical Name
1-cyclopropyl-6-fluoro-8-methoxy-7-(3-methylpiperazin-1-yl)-4-oxo-1,4-dihydroquinoline-3-carboxylic acid
Solubility
DMSO 35 mg/mL, Water
In vitro
4-Methylumbelliferone(4-MU) is a hyaluronic acid (HA) synthesis inhibitor with an IC50 of 0.4 mM. 4-MU inhibited proliferation, motility, and invasion of DU145, PC3-ML, LNCaP, C4-2B, and/or LAPC-4 cells. At IC(50) for HA synthesis (0.4 mM), 4-MU induced >3-fold apoptosis in prostate cancer cells, which could be prevented by the addition of HA. The anticancer effects of 4-MU, an orally bioavailable and relatively nontoxic agent, are primarily mediated by inhibition of HA signaling.
0
Click unfold / close
Inquiry Basket
Delete selected Quote Check Out
Decide to move out of the shopping cart?
Sure No, Back

Please choose product!

< Go Back
You have already added to buy this product