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Enzymes for Research, Diagnostic and Industrial Use

A66

Cat No.
CEI-0127
Description
A66 can inhibit p110-alpha with IC50 of 32 nM.
CAS No.
1166227-08-2
Molecular Weight
393.53
Purity
>99%
Storage
2 years at -20centigrade Powder
Targets
p110-alpha
Molecular Formula
C17H23N5O2S2
Chemical Name
(2S)-N1-(5-(2-tert-butylthiazol-4-yl)-4-methylthiazol-2-yl)pyrrolidine-1,2-dicarboxamide
Solubility
DMSO 79 mg/mL Water
In vitro
A66 is a high selective PI3K inhibitor which can inhibit PI3K-alpha with 32 nM. A66 inhibits p110-alpha E545K and p110-alpha H1047R with IC50 of 30 nM and 43 nM. A66 shows strong inhibition to p110-alpha and little inhibition to other PI3K isoform. A66 can inhibit cell lines harboring H1047R mutations in PIK3CA and have high levels of p110-alpha and class-Ia PI3K activity.
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