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Enzymes for Research, Diagnostic and Industrial Use

A-674563


Cat No.
CEI-0105
Description
A-674563
CAS No.
552325-73-2
Molecular Weight
358.44
Purity
>99%
Storage
2 years at -20 centigrade
Targets
Akt1
Molecular Formula
C22H22N4O
Solubility
No
In vitro
A-674563 can blcok the tumor cell proliferation with EC50 of 0.4 uM. A-674563 inhibit the phosphorylation of Akt downstream targets in a dose-dependent manner. In STS cells, A-674563 inhibit Akt and induce G2 cell cycle arrest and apoptosis.
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