Description
A-769662 can inhibit AMPK, AMPK alpha-1,AMPK beta-1, and AMPK gamma-1 with IC50 of 0.8 mM, 0.7 mM, 0.7 mM, and 0.7 mM.
Storage
2 years at -20centigrade Powder
Targets
AMP, AMPK alpha-1, AMPK beta-1, AMPK gamma-1
Molecular Formula
C20H12N2O3S
Chemical Name
Thieno[2,3-b]pyridine-5-carbonitrile, 6,7-dihydro-4-hydroxy-3-(2-hydroxy[1,1-biphenyl]-4-yl)-6-oxo-
Solubility
DMSO 72 mg/mL Water
In vitro
As an AMPK activators, A-769662 activates AMPK with EC 50 of 0.8 mM. A-769662 was equally potent in activating the baculovirus expressed alpha-1,beta-1,gamma-1 recombinant isoform of AMPK with EC50 of 0.7 mM. A-769662-induced AMPK activation occurs by reversible binding.
In vivo
Since AMPK activation inhibits ACC activity, there is a decrease in malonyl CoA levels, leading to reduced lipogenesis and increased fatty acid oxidation.
