Products

Enzymes for Research, Diagnostic and Industrial Use

A-769662

Cat No.
CEI-0133
Description
A-769662 can inhibit AMPK, AMPK alpha-1,AMPK beta-1, and AMPK gamma-1 with IC50 of 0.8 mM, 0.7 mM, 0.7 mM, and 0.7 mM.
CAS No.
844499-71-4
Molecular Weight
360.39
Purity
>99%
Storage
2 years at -20centigrade Powder
Targets
AMP, AMPK alpha-1, AMPK beta-1, AMPK gamma-1
Molecular Formula
C20H12N2O3S
Chemical Name
Thieno[2,3-b]pyridine-5-carbonitrile, 6,7-dihydro-4-hydroxy-3-(2-hydroxy[1,1-biphenyl]-4-yl)-6-oxo-
Solubility
DMSO 72 mg/mL Water
In vitro
As an AMPK activators, A-769662 activates AMPK with EC 50 of 0.8 mM. A-769662 was equally potent in activating the baculovirus expressed alpha-1,beta-1,gamma-1 recombinant isoform of AMPK with EC50 of 0.7 mM. A-769662-induced AMPK activation occurs by reversible binding.
In vivo
Since AMPK activation inhibits ACC activity, there is a decrease in malonyl CoA levels, leading to reduced lipogenesis and increased fatty acid oxidation.
Download Datasheet:



Inquiry
Realted Products
Catalog
ProductName
EC No.
CAS No.
Source
Price
CatalogNATE-1004
EC No.EC 2.4.2.7
CAS No.9027-80-9
SourceE. coli
CatalogNATE-1005
EC No.EC 2.4.2.7
CAS No.9027-80-9
SourceE. coli
Catalog
ProductName
EC No.
CAS No.
Source
Price
CatalogCEI-0888
ProductNameAcadesine
EC No.
CAS No.2627-69-2
Source
Online Inquiry
Name:
*Phone:
*E-mail Address:
Country:
Company/Institution:
*Products or Services Interested:
Quantity:
Project Description:
Our Products are Not Intended for Private Therapeutic Use!
*Verification Code:
Please input "enzymes"(case insensitive) as verification code.

Welcome! For price inquiries, please feel free to contact us through the form below through the form on the left side. We will get back to you as soon as possible.

Sitemap  Privacy Policy
Copyright ©2011 - 2017 Creative Enzymes.
Contact Us 45-1 Ramsey Road, Shirley, NY 11967, USA
Email: info@creative-enzymes.com
Tel: 1-631-562-8517 1-631-448-7888
Fax: 1-631-938-8127
Distributors To view the contact information for a specific location, select the desired country: