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A83-01

Cat No.
CEI-0952
Description
Potent and selective ALK4, 5 and 7 inhibitor. IC50=45, 12, 7.5 nM respectively. Prevents phosphorylation of Smad2/3 and growth inhibition induced by TGFβ. Inhibits differentiation of rat induced pluripotent stem cells and increases clonal expansion efficiency. Together with AMI-5 enabled Oct4-induced reprogramming of mouse embryonic fibroblasts. Active in rat models. Cell permeable
Abbr
A83-01(ALK)
Alias
3-(6-Methyl-2-pyridinyl)-N-phenyl-4-(4-quinolinyl)-1H-pyrazole-1-carbothioamide
Appearance
Light Yellow powder
Product Overview
ALK inhibitor
CAS No.
909910-43-6
Molecular Weight
421.5
Purity
>98% (TLC); NMR (Conforms)
Synonyms
3-(6-Methyl-2-pyridinyl)-N-phenyl-4-(4-quinolinyl)-1H-pyrazole-1-carbothioamide
Targets
ALK
Molecular Formula
C25H19N5S
Solubility
May be dissolved in DMSO (20mg/ml)
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