Products
Online Inquiry
Our Products Cannot Be Used As Medicines Directly For Personal Use.
Welcome! For price inquiries, please feel free to contact us through the form on the left side. We will get back to you as soon as possible.
ABT-888 (Veliparib)
Cat No.
CEI-0316
Description
ABT-888 can inhibit PARP-1 and PARP-2 with Ki of 5.2 nM and 2.9 nM, respectively.
CAS No.
912444-00-9
Molecular Weight
244.29
Purity
>99%
Storage
2 years at -20centigrade Powder
Targets
PARP1, PARP2
Molecular Formula
C13H16N4O
Chemical Name
(R)-2-(2-methylpyrrolidin-2-yl)-1H-benzo[d]imidazole-4-carboxamide
Solubility
DMSO 17 mg/mL Water
In vitro
As a potent inhibitor of PARP, has good oral bioavailability, can cross the blood-brain barrier, ABT-888 can inhibit PARP-1 and PARP-2 with Ki of 5.2 nM and 2.9 nM, respectively.
In vivo
ABT-888 enhanced temozolomide antitumor activity, in a dose-proportional manner with no observed toxicity in the B16F10 syngeneic melanoma model. Treatment with ABT-888 combined with temozolomide resulted in significant survival prolongation. ABT-888significantly enhanced survival in GBM12 when combined with concurrent radiotherapy/temozolomide.
Download
Download Datasheet