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AC220 (Quizartinib)

Cat No.
CEI-0055
Description
AC220 can inhibit FLT-3 ITD and FLT-3 wild type with IC50 of around 1.1 nM and 4.2 nM.
CAS No.
950769-58-1
Molecular Weight
560.67
Purity
>99%
Storage
2 years at -20centigrade Powder
Targets
Flt3(ITD), Flt3(WT)
Molecular Formula
C29H32N6O4S
Chemical Name
Urea, N-[5-(1,1-dimethylethyl)-3-isoxazolyl]-N-[4-[7-[2-(4-morpholinyl)ethoxy]imidazo[2,1-b]benzothiazol-2-yl]phenyl]-
Solubility
DMSO 33.2 mg/mL Water
In vitro
AC220 can inhibit FLT-3 ITD and FLT-3 wild type with IC50 of around 1.1 nM and 4.2 nM. AC220 inhibits cell proliferation of MV4-11 cell line with IC50 of 0.56 nM.
In vivo
Treatment with AC220 at 10 mg/kg in the MV4-11 tumor xenograft model is better than that of sunitinib.
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