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AG-879

Cat No.
CEI-0956
Description
Inhibits NGF receptor tyrosine kinase (TrkA, pp140trk). Inhibits NGF-induced neurite outgrowth in PC12 cells. Displays antitumor activity in a mouse model. Blocks the ETK-PAK1 interaction, suppressing RAS-induced PAK1 activation and malignant transformation. Cell permeable.
Abbr
AG-879(NGFR)
Alias
alpha-Cyano-(3, 5-di-t-butyl-4-hydroxy)thiocinnamide
Appearance
Yellow powder
Product Overview
NGFR inhibitor
CAS No.
148741-30-4
Molecular Weight
316.5
Purity
>99% (TLC); NMR (Conforms)
Synonyms
alpha-Cyano-(3,5-di-t-butyl-4-hydroxy)thiocinnamide
Targets
NGFR
Molecular Formula
C18H24N2OS
Melting Point
223-224ºC
Solubility
May be dissolved in DMSO (25mg/ml) or Ethanol (20 mg/ml)
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CAS No.504433-23-2
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