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AKT inhibitor VIII

Cat No.
CEI-1202
Description
A potent and selective allosteric inhibitor of Akt kinase with IC50 values of58 nM, 210 nM and 2119 nM, for Akt1, Akt2 and Akt3, respectively.
Product Overview
AKT inhibitor VIII is a cell-permeable, reversible and potent, selective inhibitor of Akt1, Akt2 and Akt3 with IC50 values of 58 nM, 210 nM and 2.12 μM, respectively. AKT inhibitor VIII has shown to remarkably increase anti-proliferation induced by furanodiene in human breast cancer cell MCF-7. AKT inhibitor VIII could enhance the furanodiene-stimulated?Akt and p-Akt expression decreases as well as increase furanodiene-induced PARP cleavage in MCF-7 cells. AKT inhibitor VIII has been revealed to inhibit?IGF-1-induced Akt phosphorylation in a concentration-dependent manner. AKT inhibitor VIII has also been demonstrated to?reduce PRAS40 phosphorylation in PC12 cells.
CAS No.
612847-09-3
Molecular Weight
551.64
Purity
0.98
Storage
Store at -20°C
Targets
Akt1; Akt2; Akt3
IC50
58 nM; 210 nM; 2119 nM
Molecular Formula
C34H29N7O
Chemical Name
3-[1-[[4-(7-phenyl-3H-imidazo[4,5-g]quinoxalin-6-yl)phenyl]methyl]piperidin-4-yl]-1H-benzimidazol-2-one
Solubility
Soluble in DMSO
Shipping Conditions
Evaluation sample solution: ship with blue ice. All other available size: ship with RT, or blue ice upon request
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