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Enzymes for Research, Diagnostic and Industrial Use

AS-604850

Cat No.
CEI-0100
Description
AS-604850
CAS No.
648449-76-7
Molecular Weight
285.22
Purity
>99%
Storage
2 years at -20 centigrade
Targets
PI3K-gamma
Molecular Formula
C11H5F2NO4S
Solubility
No
In vitro
AS-604850 is capable of inhibiting C5a-mediated PKB phosphorylation in RAW264 mouse macrophages with an IC50 with 10 uM. AS-604850 blocks MCP-1-mediated chemotaxis in Pik3cg +/+ monocytes in a concentration- dependent manner, with an IC50 of 21 mM, but dosnt affect chemotaxis in Pik3cg-/- cells, indicating that AS-604850 acts through PI3K-gamma.
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