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Alogliptin Benzoate

Cat No.
CEI-1207
Description
Alogliptin benzoate(SYR 322) is a potent, selective inhibitor of DPP-4 with an IC50 value of
Product Overview
Alogliptin is a novel, highly selective and potent inhibitor of serine protease dipeptidylpeptidase-4 (DPP-4) with IC50 value of less than 10 nM. Alogliptin has been reported to significantly reduce plasma DPP-4 activity and increase active GLP-1 levels in a dose-dependent manner in ob/ob mice. Besides, alogliptin after 4 weeks administration remarkably reduced non-fasting glycosylated hemoglobin, non-fasting plasma glucose and triglyceride levels, as well as siginificantly increased non-fasting plasma insulin and fasting pancreatic insulin content in ob/ob mice. Moreover, alogliptin treated ob/ob mice have shown the increase of early-phase insulin secretion and the decrease of plasma glucose AUC.
CAS No.
850649-62-6
Molecular Weight
461.51
Purity
0.98
Storage
Store at -20°C
Synonyms
SYR322, SYR-322,Nesina;
Targets
DPP-4
Molecular Formula
C25H27N5O4
Chemical Name
2-[[6-[(3R)-3-aminopiperidin-1-yl]-3-methyl-2,4-dioxopyrimidin-1-yl]methyl]benzonitrile; benzoic acid
Solubility
Soluble in DMSO
Shipping Conditions
Evaluation sample solution: ship with blue ice. All other available size: ship with RT, or blue ice upon request
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