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Amonafide

Cat No.
CEI-0284
Description
Amonafide
Alias
AS1413, Xanafide, Quinamed
CAS No.
69408-81-7
Molecular Weight
283.33
Purity
>99%
Storage
2 years at -20 centigrade
Synonyms
AS1413, Xanafide, Quinamed
Targets
topoisomerase II
Molecular Formula
C16H17N3O2
Solubility
No
In vitro
Amonafide interferes with the DNA breakage-reunion activity of mammalian DNA topoisomerase II resulting in DNA cleavage stimulation. Compared with those of other antitumor drugs, Amonafide-stimulated cleavage intensity patterns are markedly different. Amonafide highly prefers a cytosine, and excludes guanines and thymines instead, at position -1, with lower preference for an adenine at position +1.
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