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Apicidin

Cat No.
CEI-0495
Description
A potent, cell permeable inhibitor of histone deacetylase (IC₅₀ = 700 pM for parasitic histone deacetylase). Inhibits HeLa cell proliferation (IC₅₀ = 50 – 100 nM) and induces the transcriptional activation of p21 (WAF1) in a reversible manner. Also prevents H-ras-induced invasive phenotype of MCF-10A cells possibly by down regulating MMP-2 in a reversible manner.
Appearance
Gray solid
Product Overview
A HDAC inhibitor
CAS No.
183506-66-3
Molecular Weight
415.2
Purity
>98% by ⁵¹V-NMR
Storage
-20 centigrade
Targets
HDAC
Molecular Formula
C₃₄H₄₉N₅O₆
Chemical Name
cyclo-L-(2-Amino-8-oxodecanoyl)-L-(N-methoxy-tryptophan)-L-isoleucyl-D-pipecolinyl]Suberoylanilide hydroxamic acid
Solubility
H₂O (>5 mg/ml)
Shipping Conditions
Gel pack
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