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BCl-2 Inhibitor GX15-070

Cat No.
CEI-0406
Description
Cell-permeable. A small molecule pan–Bcl-2 antagonist that mimics BH3-only proteins by binding to multiple antiapoptotic Bcl-2 members. GX15-070 has been shown to overcome Bcl-2–, Bcl-xl–, Bcl-w–, and Mcl-1–mediated resistance to Bax or Bak. It potently interferes with the direct interaction between Mcl-1 and Bak in intact outer mitochondrial membrane and inhibits the association between Mcl-1 and Bak in intact cells.
Appearance
White solid
Product Overview
A Bcl-2 inhibitor
CAS No.
803712-67-6
Molecular Weight
175.14
Purity
>98% by NMR
Storage
-20 centigrade
Targets
Bcl-2
Molecular Formula
C 18 H 29 N 3 O
Chemical Name
(Z)-2-(2-((3,5-dimethyl-1H-pyrrol-2-yl)methylene)-3-methoxy-2H-pyrrol-5-yl)-1H-indole
Solubility
DMSO (100 mM) or H₂O (100 mM)
Shipping Conditions
Gel pack
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