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BIIB 021

Cat No.
CEI-0536
Description
A synthetic, small molecule Hsp90 inhibitor that binds competitively with geldanamycin in the ATP-binding pocket of Hsp90. In tumor cells, BIIB021 induces the degradation of Hsp90 client proteins including HER-2, AKT, and Raf-1 and up-regulates expression of the heat shock proteins Hsp70 and Hsp27. BIIB021 inhibits the proliferation of N87, MCF-7, and BT474 tumor cells with IC50 values of 0.06, 0.31, and 0.14 µM, respectively.
Alias
CNF2024
Appearance
Light pink solid
Product Overview
A potent Hsp90 inhibitor
CAS No.
848695-25-0
Molecular Weight
645.83
Purity
>95% by HPLC
Storage
-20 centigrade
Synonyms
CNF2024
Targets
HSP90
Molecular Formula
C 14 H 15 ClN 6 O
Chemical Name
6-Chloro-9-[(4-methoxy-3,5-dimethyl­-2-pyridinyl)methyl]-9H-purin-2-amine
Solubility
DMSO (>10 mg/ml) or H₂O (>10 mg/ml)
Shipping Conditions
Gel pack
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