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BML-277

Cat No.
CEI-0960
Description
A highly selective inhibitor of Chk2 (IC50=15 nM). Displays <25% inhibition of 35 other kinases at 10 uM). It possesses potent radioprotective activity and prevents apoptosis of human T-cells subjected to ionizing radiation (EC50= 3-7.6 μM). It is a useful tool for determining the role of Chk2 in cellular signaling.
Abbr
BML-277(CHEK2)
Alias
2-(4-(4-chlorophenoxy)phenyl)-1H-benzimidazole-5-carboxamide, Chk2 Inhibitor II
Appearance
Off white solid
Product Overview
CHK2 inhibitor
CAS No.
516480-79-8
Molecular Weight
363.8
Purity
>98% (TLC; 1:1 ethylacetate: hexane; Rf=0.17); NMR (Conforms)
Synonyms
2-(4-(4-chlorophenoxy)phenyl)-1H-benzimidazole-5-carboxamide, Chk2 Inhibitor II
Targets
CHK2
Molecular Formula
C20H14ClN3O2
Solubility
May be dissolved in DMSO (20 mg/ml); or Ethanol (20 mg/ml)
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CatalogNATE-0122
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SourceE. coli
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