Products

Enzymes for Research, Diagnostic and Industrial Use

BMS 777607

Cat No.
CEI-0069
Description
BMS 777607 can inhibit c-Met with IC50 of 20 nM.
CAS No.
1196681-44-3
Molecular Weight
512.89
Purity
>99%
Storage
2 years at -20centigrade Powder
Targets
c-Met
Molecular Formula
C25H19ClF2N4O4
Chemical Name
N-(4-(2-amino-3-chloropyridin-4-yloxy)-3-fluorophenyl)-4-ethoxy-1-(4-fluorophenyl)-2-oxo-1,2-dihydropyridine-3-carboxamide
Solubility
DMSO 47 mg/mL Water
In vitro
BMS-777607 is a novel, selective, and orally available ATP-competitive Met kinase inhibitor that specifically targets several Met family members and potently binds to the c-Met active site with a Ki value of 3.9 nmol/L. BMS-777607 potently blocked the autophosphoryla-tion of c-Met with an IC 50 of 20 nmol/L. BMS-777607 can inhibit HGF-induced prostate cancer cell scattering, suppress HGF-induced cell migration, impair HGF-mediated cell invasion and reduce cell proliferation increased by HGF. BMS-777607 can also block HGF-stimulated c-Met downstream signaling pathway
In vivo
Oral administration of BMS 777607 (6.25-50 mg/kg) significantly reduces tumor volumes of the GTL-16 human tumor xenografts in athymic mice with no observed toxicity.
Download Datasheet:



Inquiry
Related Products
Catalog
ProductName
EC No.
CAS No.
Source
Price
CatalogCEI-0006
EC No.
CAS No.905854-02-6
Source
CatalogCEI-0029
ProductNameBMS 794833
EC No.
CAS No.1174046-72-0
Source
CatalogCEI-0032
ProductNameAMG458
EC No.
CAS No.913376-83-7
Source
CatalogCEI-0034
ProductNameAMG-208
EC No.
CAS No.1002304-34-8
Source
+ See More >>
Online Inquiry
Name:
*Phone:
*E-mail Address:
Country:
Company/Institution:
*Products or Services Interested:
Quantity:
Project Description:
Our Products are Not Intended for Private Therapeutic Use!
*Verification Code:
Please input "enzymes"(case insensitive) as verification code.

Welcome! For price inquiries, please feel free to contact us through the form on the left side. We will get back to you as soon as possible.


Sitemap  Privacy Policy  Terms and Conditions
Copyright ©2011 - 2018 Creative Enzymes.
Contact Us 45-1 Ramsey Road, Shirley, NY 11967, USA
Email: info@creative-enzymes.com
Tel: 1-631-562-8517 1-516-512-3133
Fax: 1-631-938-8127
Distributors To view the contact information for a specific location, select the desired country:
0
Click unfold / close
Inquiry Basket
Delete selected Check Out
Decide to move out of the shopping cart??

Sure No, Back
 

Please choose product!

< Go Back
You have already added to buy this product