Products
Online Inquiry
Our Products Cannot Be Used As Medicines Directly For Personal Use.
Welcome! For price inquiries, please feel free to contact us through the form on the left side. We will get back to you as soon as possible.
BMS-599626 (AC480)
Cat No.
CEI-0019
Description
BMS-599626 (AC480)
CAS No.
873837-23-1
Molecular Weight
567.01
Purity
>99%
Storage
2 years at -20 centigrade
Targets
HER1, HER2
Molecular Formula
C27H27FN8O3.HCl
Solubility
No
In vitro
BMS-599626(AC480) inhibited HER1 and HER2 with IC50 of 20 and 30 nM. BMS-599626(AC480) is highly selective against a broad panel of diverse protein kinases. BMS-599626 abrogated HER1 and HER2 signaling and inhibited the proliferation of tumor cell lines that are dependent on these receptors, with IC50 in the range of 0.24 to 1 micromol/L. In tumor cells that are capable of forming HER1/HER2 heterodimers, BMS-599626 inhibited heterodimerization and downstream signaling. BMS-599626(AC480) significantly enhanced the radiosensitivity of HN-5 cells. In HN-5 cells, BMS-599626(AC480) inhibit the expression of pEGFR, pHER2, cyclins D and E, pRb, pAkt, pMAPK, pCDK1 and 2, CDK 6, and Ku70 proteins. BMS-599626(AC480) also induced accumulation of cells in the G1 cell cycle phase, inhibited cell growth, enhanced radiosensitivity, and prolonged the presence of gamma-H2AX foci up to 24 h after radiation.But BMS-599626(AC480) did not increase the percentage of cells undergoing radiation-induced apoptosis.
Download
Download Datasheet