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Borrelidin

Cat No.
CEI-0401
Description
A macrolide antibiotic isolated from Streptomyces sp. An antiangiogenic (IC50 = 0.8 nM) agent. Bacterial and eukaryal threonyl-tRNA synthetase (THrRS) inhibitor. Induces the collapse of formed capillary tubes in a dose-dependent fashion. In HUVECs, the capillary tube collapsing activity is mediated by the activation of caspases-3 and -8 and induction of apoptosis. Also acts as a CDK inhibitor.
Alias
Treponemycin; U 78548; C2989
Appearance
White to off-white solid
Product Overview
An angiogenesis inhibitor
CAS No.
7184-60-3
Molecular Weight
274.18
Purity
>99%
Storage
-20 centigrade
Synonyms
Treponemycin; U 78548; C2989
Targets
Angiogenesis
Molecular Formula
C 28 H 43 NO 6
Solubility
DMSO (~ 5 mg/ml)
Shipping Conditions
Gel pack
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