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Bromodomain Inhibitor, (+)-JQ1

Cat No.
CEI-0409
Description
Cell-permeable. A potent and highly specific inhibitor for the BET (bromodomain and extra-terminal) family of bromodomains. (+)-JQ1 binds to BRD4 bromodomains 1 and 2 with Kd values of ~ 50 and 90 nM, respectively. The binding is competitive with acetyl lysine. (+)-JQ1 can be a useful chemical probe to investigate the role of BET bromodomains in the transcriptional regulation of oncogenesis.
Appearance
Crystalline solid
Product Overview
A potent and highly specific BET inhibitor
CAS No.
1268524-70-4
Molecular Weight
349.43
Purity
>99% by HPLC
Storage
-20 centigrade
Targets
BRD4
Molecular Formula
C23H25ClN4O2S
Chemical Name
t-Butyl-2-((6S)-4-(4-chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl)acetate
Solubility
DMSO
Shipping Conditions
RT
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