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CGS 21680

Cat No.
CEI-1277
Description
CGS 21680 is agonist of A2A adenosine receptor with Ki value of 27 nM.
Product Overview
CGS 21680 is a selective agonists of A2 adenosine receptor with IC50 value of 22nM. CGS 21680 is found to be potent and selective adenosine A2 receptor agonists. In a radioligand binding in vitro assay, CGS 21680 binds A2 receptor with IC50 value of 22nM and the A1/A2 ratio is 141, In the perfused rat heart model, CGS 21680 can increase coronary flow with greater EC25 value than 1000nM. It shows a good separation between its ability to induce vasorelaxation and bradycardia. CGS 21680 also has potent effect on blood pressure in vivo with EC25 value of 9µg/kg and it can induce an increase in heart rate. It is reported that CGS 21680 also has the potency of anti-inflammatory. It can reduce the development of acute lung inflammation in a mouse model of carrageenan-induced pleurisy. In both prior and post-treatment, CGS 21680 can reduce the number of inflammatory cells and the degree of lung injury.
CAS No.
120225-54-9
Molecular Weight
499.52
Purity
0.98
Storage
Store at -20°C
Synonyms
CGS-21680; CGS21680
Targets
A2A adenosine receptor
IC50
27 nM (Ki)
Molecular Formula
C23H29N7O6
Chemical Name
3-[4-[2-[[6-amino-9-[(2R,3R,4S,5S)-5-(ethylcarbamoyl)-3,4-dihydroxyoxolan-2-yl]purin-2-yl]amino]ethyl]phenyl]propanoic acid
Solubility
Soluble in DMSO
Shipping Conditions
Evaluation sample solution: ship with blue ice. All other available size: ship with RT, or blue ice upon request
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