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CHIR-124

Cat No.
CEI-0285
Description
CHIR-124
CAS No.
405168-58-3
Molecular Weight
419.91
Purity
>99%
Storage
2 years at -20 centigrade
Targets
Chk1
Molecular Formula
C23H22ClN5O
Solubility
No
In vitro
CHIR-124 is a quinolone-based small molecule that is structurally unrelated to other known inhibitors of Chk1. CHIR-124 interacts synergistically with topoisomerase poisons (e.g., Camptothecin or SN-38) in causing growth inhibition in a variety of cancer cell lines, including breast carcinoma (MDA-MB-231 and MDA-MB-435) and colon carcinoma (SW-620 and Colo205), all of which contains the mutant p53 gene.
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