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Enzymes for Research, Diagnostic and Industrial Use

CHIR-99021(CT99021)

Cat No.
CEI-0123
Description
CT99021(CHIR-99021) can inhibit GSK3alpha and GSK3beta with IC50 of 10 nM and 6.7 nM.
CAS No.
252917-06-9
Molecular Weight
465.34
Purity
>99%
Storage
2 years at -20centigrade Powder
Targets
GSK3alpha, GSK3beta
Molecular Formula
C22H18Cl2N8
Chemical Name
6-(2-(4-(2,4-dichlorophenyl)-5-(4-methyl-1H-imidazol-2-yl)pyrimidin-2-ylamino)ethylamino)nicotinonitrile hydrochloride
Solubility
DMSO 100 mg/mL Water 100 mg/mL Ethanol 20 mg/mL
In vitro
As a potent inhibitor, CT99021(CHIR-99021) can inhibit GSK3alpha and GSK3beta with IC50 of 10 nM and 6.7 nM. Inhibition of GSK3 with CT99021 (3 microM) resulted in a significant increase in the percentage and quality of blastocysts. CT99021 can reduced the phosphorylation of beta-catenin on Ser45 in two-cell embryos.
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