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Enzymes for Research, Diagnostic and Industrial Use

CUDC-101

Cat No.
CEI-0982
Description
CUDC-101 is a potent inhibitor of histone deacetylase (HDAC) and the receptor kinases epidermal growth factor receptor (EGFR) and human epidermal growth factor receptor 2 (HER2), with IC50 values of 4.4, 2.4, and 15.7 nM, respectively. It inhibted EGFR and Her2 phosphorylation, reduced cell proliferation and induced apoptosis in HCC827 non-small cell lung cancer (NSCLC) xenografts. CUDC-101 inhibited EGFR and induced upregulation of acetylated histone H3 in a dose-dependent fashion.
Abbr
CUDC-101
Appearance
White solid.
CAS No.
1012054-59-9
Molecular Weight
434.5 Da
Purity
>99%
Stability
Store at or below –20°C. Solid form is stable at least 12 months from date of receipt, when stored as directed. Do not store aqueous solutions for more than one day.
Targets
HDAC, EGFR, HER2
IC50
HDAC、EGFR、HER2 : 4.4, 2.4, and 15.7 nM respectively
Molecular Formula
C24H26N4O4
Solubility
Soluble in DMSO at 28 mg/ml; very poorly soluble in ethanol; very poorly soluble in water; maximum solubility in plain water is estimated to be about 20-50 µM; buffers, serum, or other additives may increase or decrease the aqueous solubility.
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