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Calpain Inhibitor I, ALLN

Cat No.
CEI-0414
Description
A cell-permeable inhibitor of calpain I (Ki = 190 nM), calpain II (Ki = 220 nM), cathepsin B (Ki = 150 nM), and cathepsin L (Ki = 0.5 nM). Inhibits neutral cysteine proteases and the proteasome (Ki = 6 µM). Can initiate apoptosis in HL-60 cells but blocks dexamethasone-induced apoptosis in thymocytes and cycloheximide-induced apoptosis in metamyelocytes. Inhibits cyclin B degradation and arrests the cell cycle at G1/S and at meta-/anaphase.
Alias
Ac-LLnL-CHO, MG-101, N-Acetyl-L-leucyl-L-leucyl-L-norleucinal, N-Acetyl-Leu-Leu-Nle-al
Appearance
White to off-white solid
Product Overview
A Calpain inhibitor
CAS No.
110044-82-1
Molecular Weight
692.71
Purity
>98%
Storage
RT
Synonyms
Ac-LLnL-CHO, MG-101, N-Acetyl-L-leucyl-L-leucyl-L-norleucinal, N-Acetyl-Leu-Leu-Nle-al
Targets
calpain I, calpain II, cathepsin B, cathepsin L
Molecular Formula
C₂₀H₃₇N₃O₄
Solubility
H₂O (50 mg/ml)
Shipping Conditions
RT
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