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Canagliflozin

Cat No.
CEI-1262
Product Overview
Canagliflozin is a novel, potent, and highly selective sodium glucose co-transporter (SGLT) 2 inhibitor. It has been proved that Canagliflozin can increase urine glucose excretion by reducing the renal glucose threshold and by decreasing the filtered glucose re-absorption. Canagliflozin has been shown to inhibit the Na+-mediated 14C-AMG intakes in CHO-hSGLT2, CHO-rat SGLT2 and CHO-mouse SGLT2 with IC50 values of 4.4, 3.7 and 2.0 nM, respectively. Canagliflozin has been reported to reduce the blood glucose (BG) levels dose-dependently in both db/db Mice and Zucker diabetic fatty (ZDF) Rats. Additionally, canagliflozin has proved to decrease the respiratory exchange ratio, and body weight in DIO mice and ZDF rats. Canagliflozin can be taken orally.
CAS No.
842133-18-0
Molecular Weight
444.52
Purity
0.9977
Storage
Store at -20°C
Synonyms
JNJ 24831754ZAE; JNJ 28431754; JNJ 28431754AAA; TA 7284
Targets
hSGLT2; rSGLT2; mSGLT2
IC50
4.4 nM; 3.7 nM; 2 nM
Molecular Formula
C24H25FO5S
Chemical Name
(2S,3R,4R,5S,6R)-2-[3-[[5-(4-fluorophenyl)thiophen-2-yl]methyl]-4-methylphenyl]-6-(hydroxymethyl)oxane-3,4,5-triol
Solubility
Soluble in DMSO > 10 mM
Shipping Conditions
Evaluation sample solution: ship with blue ice. All other available size: ship with RT, or blue ice upon request
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