Description
Cathepsin K, a member of the papain cysteine proteinase family is the predominant proteinase responsible for the resorption of the bone matrix. Cathepsin cleaves proteins such as collagen type I, collagen type II and osteonectin, thereby playing a role in bone remodeling and resorption in osteoporosis, osteolytic bone metastasis and rheumatoid arthritis.
Abbr
CTSK, Recombinant (Human)
Enzyme Commission Number
EC 3.4.22.38
Activity
>900 mU/mg protein
Unit Definition
One unit is defined as the amount of enzyme that will hydrolyze 0.4 µmol Z-FR-AMC per min at 37°C, pH 5.5.
Storage
at –80°C. Avoid freeze/thaw
Synonyms
CTSK; CTSO; CTSO3; Cathepsin O; Cathepsin O2; Cathepsin X; EC 3.4.22.38
