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Ciluprevir (BILN-2061)

Cat No.
CEI-1283
Product Overview
Ciluprevir is a selective inhibitor of NS3 protease with IC50 value of 3.0 nM. NS3 (non-structural protein 3) protease is a protein whose C-terminal two-thirds contain a helicase and nucleic acid-stimulated NTPase activities and plays a pivotal role in HCV replication. It is reported that NS3 has regarded as a target to control HCV RNA replication via designing new drugs to inhibit it. Ciluprevir is a NS3 protease inhibitor and has a different affinity with the reported NS3 protease inhibitor VX-950.When using covalent adducts formation method, Svahn Gustafsson S found that ciluprevir showed faster association and slower dissociation kinetics. NS3.4 protease inhibitor ciluprevir has potential for treating chronic HCV and robust antiviral activities have been reported. Furthermore, treatment HCV patients with ciluprevir showed significant HCV RNA reduction in plasma levels in clinical.
CAS No.
300832-84-2
Molecular Weight
774.93
Purity
0.98
Storage
Store at -20°C
Synonyms
BILN 2061; BILN 2061ZW
Targets
HCV NS3 protease
Molecular Formula
C40H50N6O8S
Solubility
Soluble in DMSO
Shipping Conditions
Evaluation sample solution: ship with blue ice. All other available size: ship with RT, or blue ice upon request
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