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Cucurbitacin I

Cat No.
CEI-1077
Description
Selective inhibitor of STAT3/JAK2 signaling. Inhibits the activation of STAT3 and JAK2 and displays no activity on Src, Akt, ERK and JNK. Suppresses phosphotyrosine levels of STAT3, inhibits STAT3 DNA binding and STAT3-mediated gene expression. Induces apoptosis in cell lines expressing constitutively active tyrosine-phosphorylated STAT3.
Abbr
Cucurbitacin I(STAT3, JAK2)
Alias
APRF, HIES
CAS No.
2222-07-3
Molecular Weight
514.65
Purity
>98 %
Stability
Stable under recommended storage conditions.
Storage
-20 centigrade
Synonyms
APRF, HIES
Targets
STAT3, JAK2
Molecular Formula
C30H42O7
Chemical Name
(9β,10α,16α,23E)-2,16,20,25-Tetrahydro​xy-9-methyl-19-norlanosta-1,5,23-triene-3,11,22-tr​ione
Solubility
Soluble to 10 mM in DMSO and to 20 mM in ethanol
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