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Disulfiram
Cat No.
CEI-0377
Description
Disulfiram can inhibit V-ATPase with EC50 of 26 uM.
Alias
Antabuse, Antabus
CAS No.
57852-57-0
Molecular Weight
296.54
Purity
>99%
Storage
2 years at -20centigrade Powder
Synonyms
Antabuse, Antabus
Targets
V-ATPase
Molecular Formula
C26H27NO9.HCl
Chemical Name
(7S,9S)-9-acetyl-7-((2R,4S,5S,6S)-4-amino-5-hydroxy-6-methyl-tetrahydro-2H-pyran-2-yloxy)-6,9,11-trihydroxy-7,8,9,10-tetrahydrotetracene-5,12-dione hydrochloride
Solubility
DMSO 107 mg/mL, Water 10 mg/mL, Ethanol
In vitro
Disulfiram is an agent used to support the treatment of chronic alcoholism by producing an acute sensitivity to alcohol. Disulfiram is also being studied as a treatment for cocaine dependence, as it prevents the breakdown of dopamine (a neurotransmitter whose release is stimulated by cocaine); the excess dopamine results in increased anxiety, higher blood pressure, restlessness and other unpleasant symptoms. Several studies have reported that it has anti-protozoal activity as well. [1] Disulfiram can inhibit V-ATPase with EC50 of 26 uM. Disulfiram can stimulate reversibly the Ca(2+)-ATPase of skeletal muscle sarcoplasmic reticulum. Disulfiram can double the ATPase activity at the concerntration of 120 microM. Disulfiram can increase the rate of dissociation of Ca2+ from the phosphorylated ATPase and the rate of dephosphorylation of the phosphorylated ATPase, but shows no effect on the Ca2+ affinity of the ATPase. Disulfiram can inhibit expression of MMP-2 and MMP-9.
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