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Dovitinib Dilactic acid (TKI258 Dilactic acid)

Cat No.
CEI-0027
Description
Dovitinib Dilactic acid (TKI258 Dilactic acid)
Alias
CHIR-258 Dilactic acid
CAS No.
852433-84-2
Molecular Weight
572.59
Purity
>99%
Storage
2 years at -20 centigrade
Synonyms
CHIR-258 Dilactic acid
Targets
FLT3
Molecular Formula
C21H21FN6O.2C3H6O3
Solubility
No
In vitro
Dovitinib Dilactic acid (TKI258 Dilactic acid) is a highly potent, novel multitargeted growth factor receptor kinase inhibitor with IC50 of 1, 2, 10, 8, 27, 36 nM for FLT3, c-KIT, VEGFR1/2/3, PDGFR? and CSF-1R. Dovitinib Dilactic acid (TKI258 Dilactic acid) potently inhibits FGFR3 with an inhibitory concentration of 50% (IC50) of 5 nM in in vitro kinase assays and selectively inhibited the growth of B9 cells and human myeloma cell lines expressing wild-type (WT) or activated mutant FGFR3.
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