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Dutasteride

Cat No.
CEI-0210
Description
Dutasteride
Alias
GI198745, GG-745
CAS No.
164656-23-9
Molecular Weight
528.53
Purity
>99%
Storage
2 years at 20centigrade Powder
Synonyms
GI198745, GG-745
Targets
5 alpha-reductase
Molecular Formula
C27H30F6N2O2
Chemical Name
(4aR,4bS,6aS,7S,9aS,9bS,11aR)-N-(2,5-bis(trifluoromethyl)phenyl)-4a,6a-dimethyl-2-oxo-2,4a,4b,5,6,6a,7,8,9,9a,9b,10,11,11a-tetradecahydro-1H-indeno[5,4-f]quinoline-7-carboxamide
Solubility
DMSO 62 mg/mL, Water
In vitro
Dutasteride is a 5-alpha-reductase inhibitor that inhibits the conversion of testosterone into dihydrotestosterone (DHT). It is used for the treatment of benign prostatic hyperplasia (BPH) and is prescibed off-label for the treatment of male pattern baldness (MPB). Dutasteride inhibits both isoforms of 5-alpha reductase (5aR1 and 5aR2) to a similar extent (IC50 6nmol/l and 7 nmol/l, respectively), while finasteride only inhibits Type II. Dutasteride competed for binding the LNCaP cell AR with an IC(50) approximately 1.5 ?M.
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