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exo-α-Sialidase from Salmonella typhimurium, Recombinant

Cat No.
NATE-1125
Description
Neuraminidase enzymes are glycoside hydrolase enzymes (EC 3.2.1.18) that cleave the glycosidic linkages of neuraminic acids. Neuraminidase enzymes are a large family, found in a range of organisms. The best-known neuraminidase is the viral neuraminidase, a drug target for the prevention of the spread of influenza infection. The viral neuraminidases are frequently used as antigenic determinants found on the surface of the Influenza virus. Some variants of the influenza neuraminidase confer more virulence to the virus than others. Other homologs are found in mammalian cells, which have a range of functions. At least four mammalian sialidase homologs have been described in the human genome (see NEU1, NEU2, NEU3, NEU4).
Abbr
exo-α-Sialidase, Recombinant (S. Typhimurium)
Source
Salmonella typhimurium
Applications
High purity recombinant exo-alpha-Sialidase (S. Typhimurium) for use in research, biochemical enzyme assays and in vitro diagnostic analysis.
Form
Solution in 20 mM Tris.HCl pH 7.5, 50 mM NaCl, 5 mM EDTA plus 0.02% (w/v) sodium azide.
Enzyme Commission Number
EC 3.2.1.18
Activity
802 U/mg protein (on pNP-α-D-N-acetylneuraminic acid) at pH 7.0 and 37°C.
CAS No.
9001-67-6
Molecular Weight
~ 42,900
Isoelectric point
~ 8.5
Specificity
Hydrolysis of unbranched, non-reducing terminal α-2,3-linked >> α-2,6-linked >> α-2,8-linked N-acetylneuraminic acid (NANA; Neu5Ac) residues from glycoproteins and oligosaccharides of glycoconjugates.
Unit Definition
One Unit of sialidase activity is defined as the amount of enzyme required to release one µmole of p-nitrophenol per minute from pNP-α-D-N-acetylneuraminic acid (1 mM) in sodium phosphate buffer (100 mM) pH 7.0 and 37°C, monitored at 410 nm.
Optimum pH
5.5 - 7.0
Storage
4°C
Synonyms
neuraminidase; sialidase; α-neuraminidase; acetylneuraminidase; exo-α-sialidase; EC 3.2.1.18; 9001-67-6
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Realted Protocols
neuraminidase -Enzymatic Assay Protocol
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