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Enzymes for Research, Diagnostic and Industrial Use

FAS Inhibitor, C75

Cat No.
CEI-0481
Description
Inhibitor of fatty acid synthase (FAS) reducing food intake and body weight in mice. Exhibits irreversible slow-binding biphasic inactivation of FAS. Down regulates neuropeptide Y and Agouti-related protein expression. Has been proposed to activiate CPT-1 activity in liver and adipose tissue, leading to increased fatty acid oxidation and energy production. Shows significant in vivo antitumor activity in human breast cancer cells.Suppresses DNA replication and induces apoptosis. FAS inhibition by C75 leads to dramatic accumulation of the CDK inhibitor p27KIP1 from cytosol to cell nuclei.
Appearance
White solid
Product Overview
A FAS inhibitor
CAS No.
191282-48-1
Molecular Weight
515.86
Purity
>98% by TLC
Storage
-20 centigrade
Targets
FASN
Molecular Formula
C₁₄H₂₂O₄
Chemical Name
4-Methylene-2-octyl-5-oxotetrahydrofuran-3-carboxylic acid
Solubility
H₂O (100 mM)
Shipping Conditions
RT
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CAS No.17397-89-6
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